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In SMA, individuals lack a working copy of the SMN1 gene, and the ASOs are used to facilitate proper splicing of the SMN2 gene through inducing the inclusion of exon 7ultimately rescuing the expression of the SMN protein within in vitro mammalian cell models [91] In 2016, the FDA authorized the use of Spinraza, the first drug-based therapy for SMA [93]

A 2018 clinical study: In the study of 71 women, a facial cream containing GHK-Cu was applied daily for 12 weeks

10.1016/S0168-3659(97)00101-6 [DOI] [PubMed] [Google Scholar] 261.Brayden DJ, Gleeson J, Walsh EG